商品介绍
| Description | FUNCTION:Requiredforautophagy.ConjugatestoATG12andassociateswithisolationmembranetoformcup-shapedisolationmembraneandautophagosome.Theconjugatedetachesfromthemembraneimmediatelybeforeorafterautophagosomeformationiscompleted.FUNCTION:Mayplayanimportantroleintheapoptoticprocess,possIBLywithinthemodifiedCytoskeleton.Itsexpressionisarelativelylateeventintheapoptoticprocess,occurringdownstreamofcaspaseactivity.SUBCELLULARLOCATION:Cytoplasm.Colocalizeswithnonmuscleactin.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Ubiquitous.ThemRNAispresentatsimilarlevelsinviableandapoptoticcells,whereastheproteinisdramaticallyhighlyexpressedinapoptoticcells.INDUCTION:Byapoptoticstimuli.PTM:ConjugatedtoATG12;whichisessentialforautophagy,butisnotrequiredforassociationwithisolationmembrane.SIMILARITY:BelongstotheATG5family. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | AsyntheticpeptidecorrespondingtotheC-terminalofhumanATG-5L.Noimmunogeniccarrierproteinwasconjugatedtotheimmunogen.Instead,AdjukineBhasbeenusedtoorchestrate/boosttheimmuneresponse. |
| OtherNames | Autophagyprotein5;APG5-like;APG5;Apoptosis-specificprotein;APG5;ATG5;APG5L;ASP |
| Accession | ATG5_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,immunofluorescence,WB.Adilutionof1:200to1:1000dilutionisrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | IHCandWBconfirmedthespecificityforATG5. |
| Cross-reactivity | Human,notyettestedinotherspecies. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.E.N.Wilsonetal(2011)ASwitchBetweenCytoprotectiveandCytotoxicAutophagyintheRADIosensitizationofBreastTumorCellsbyChloroquineandVitaminD.HormCancer.2011Sep2. 2.BristolMLetal(2012)Dualfunctionsofautophagyintheresponseofbreasttumorcellstoradiation:cytoprotectiveautophagywithradiationaloneandcytotoxicautophagyinradiosensitizationbyvitaminD3.Autophagy.2012May1;8(5):739-53. 3.GuidoCetal(2012)Metabolicreprogrammingofcancer-associatedfibroblastsbyTGF-βdrivestumorgrowth:connectingTGF-βsignalingwith"Warburg-like"cancermetabolismandL-lactateproduction.CellCycle.2012Aug15;11(16):3019-35. |
| References | 1.Mizushima,Netal.(2003)IntJBiochemCellBiol.35(5),553-61 2.BaehreckeEH.NatRevMolCellBiol.6(6):505-10.(2005) 3.LumJJ,etal.NatRevMolCellBiol.6(6):439-48.(2005) 4.GreenbergJT.DevCell.8(6):799-801.(2005) |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
Sensory Nervous System
PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
Cell Markers
PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
Other Neuronal
Neurotransmitters & Enzymes
Antioxidant Enzymes
Neuronal Markers
Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
销售排行
厂家直采
全球直采 正品优价
正品保障
厂家直发 有线跟踪
正规清关
CIF100%正规报关，提供发票
及时交付
限时必达 不达必赔
总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏ 0512-67156496（苏州）
版权信息：
© 2015- 苏州蚂蚁淘生物科技有限公司 版权所有 中国
友情链接：
联系QQ:764052152
免责声明：
本站有部分内容来自互联网，如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权，请来电或致函告之，
本网站将在规定时间内给予删除等相关处理。
本网站将在规定时间内给予删除等相关处理。
扫描二维码关注官方微信
获取最新促销及产品信息