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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit antibody to ATG3: whole serum/R-159-100/100 µl
产品编号:R-159-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit antibody to ATG3: whole serum/R-159-100/100 µl
商品介绍
DescriptionFUNCTION:GABARAPL1(GABARAPL2orGABARAPorMAP1LC3)-modifierproteinconjugatingenzymeinvolvedinitsE2-likecovalentbindingtoPE.ATG7(E1-likeenzyme)facilitatesthisreactionbyforminganE1-E2complexwithATG3(E2-likeenzyme).PreferredsubstrateisMAP1LC3A.FormationoftheGABARAPL1-PEconjugateisessentialforautophagy.SUBUNIT:InteractswithATG7andATG12.Thecomplex,composedofATG3andATG7,playsaroleintheconjugationofATG12toATG5.SUBCELLULARLOCATION:Cytoplasm.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Widelyexpressed,withahighestexpressioninheart,skeletalmuscle,kidney,liverandplacenta.SIMILARITY:BelongstotheATG3family.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptidecorrespondingtoacentralregionofthehumanATG3proteinconjugatedtoBlueCarrierProteinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromATG3proteininmouse,rat,S.cerevisiae,Macacamulatta(monkey)andCanisfamiliaris(dog).
OtherNamesAutophagy-relatedprotein3;APG3;APG3-like;hApg3;ProteinPC3-96;ATG3;APG3;APG3L
AccessionATG3_HUMAN
ATG3_MOUSE
ATG3_RAT
ATG3_Saccharomycescerevisiae
ATG3_Macacamulatta
ATG3_Canisfamiliaris
ProducedinRabbit
PurityWholeserum
ApplicationsIHC,WB,immunofluorescence.Adilutionof1:50to1:3000dilutionisrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityIHC,WBandELISAconfirmedthespecificityforATG3.A37kDaband,thatcorrespondstothemolecularweightofATG3,isdetectedviawesternblotanalysis.
Cross-reactivityHuman,rat,mouse.Otherspeciesnotyettested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferences1.RyningenAetal(2012)InhibitionofMammaliantargetofrapamycininhumanacutemyeloidleukemiacellshasdiverseeffectsthatdependontheenvironmentalinvitrostress.BoneMarrowRes.2012;2012:329061.
References1.TanidaI,etal.J.Biol.Chem.277:13739-13744(2002).
2.OtaT,etal.Nat.Genet.36:40-45(2004).
3.RushJ,etal.Nat.Biotechnol.23:94-101(2005).
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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