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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Mouse monoclonal antibody to MAP1LC3A (11-23), [Clone BS405]: IgG/M-1725-100/100 µg
产品编号:M-1725-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Mouse monoclonal antibody to MAP1LC3A (11-23), [Clone BS405]: IgG/M-1725-100/100 µg
商品介绍
DescriptionMAP1AandMAP1Baremicrotubule-associatedproteinwhichmediatethephysicalinteractionsbetweenmicrotubulesandcomponentsoftheCytoskeleton(probablyinvolvedinautophagosomeformation).MAP1AandMAP1Beachconsistofaheavychainsubunitand3differentlightchainsubunits(LC1,LC2andLC3).MAP1LC3AisoneofthelightchainsubunitsandcanassociatewitheitherMAP1AorMAP1B.TheprecursorformofMAP1LC3AiscleavedbyAPG4/ATG4BtoformthecytosolicformLC3-1.ThisisactivatedbyAPG7L/ATG7,transferredtoATG3andconjugatedtophospholipidtoformthemembrane-boundform,LC3-II.MAP1LC3Aismostabundantinheart,brain,liver,skeletalmuscleandtestisbutisabsentinthymusandperipheralleukocytes.
BatchNo.Pleaserefertotheproductlabel.
Unitsize100µg
AntigenAsyntheticpeptide(C-RSFADRCKEVQQI)correspondingtoaminoacids11-23ofhumanMAP1LC3Aproteinwasconjugatedtoacarrierproteinandthecomplexusedastheimmunogen.ThishumansequenceishomologouswithmouseandratMAP1LC3A.
SequenceRSFADRCKEVQQI
AntigenLocationIntracellular,cytosolic
AntigenLength13aminoacids
AntibodyTypeMousemonoclonalIgG
IsotypeIgG2a,k-lightchain
CloneBS405
OtherNamesMicrotubule-associatedproteins1A/1Blightchain3A;MAP1A/MAP1BLC3A;MAP1A/1Blightchain3A;MAP1lightchain3-likeprotein1;Microtubule-associatedprotein1lightchain3alpha;Autophagy-relatedproteinLC3A;Autophagy-relatedubiquitin-likemodifierLC3A;APG8a;MAP1LC3A
AccessionMLP3A_HUMAN
MLP3A_MOUSE
MLP3A_RAT
ProducedinMouse
MolecularWeightThebroadbandseenonWBindicatestheantibodydetectsboththecytosolicLC3-Iandautophagosomemembrane-boundLC3-IIformswithapparentmolecularweightsof~14kDa(LC3-I)and~12kDa(LC3-II).
PurityProteinGpurifiedmouseimmunoglobulin
ApplicationsFlowCytometry(20µg/mL),Westernblot(10µg/mL),Immunocytochemistry(1-2µg/mL).Otherapplicationshavenotyetbeentested.Biosensisrecommendsoptimaldilutionsandconcentrationsshouldbedeterminedbytheenduser.
SpecificityWBconfirmedbindingoftheantibodytoabroadproteinbandwithaMolecularWeightof~14kDa.
SpeciesAgainstHuman
Cross-reactivityRat.TheantibodyisexpectedtoreactwithmouseMAP1LC3Aproteindueto100%sequencehomology.
FormLyophilizedfromPBS,pH7.4,containing3%trehalosewithoutpreservatives.
ReconstitutionReconstitutein100µLofsterilewater.Centrifugetoremoveanyinsolublematerial.Finalbuffercontainsnopreservatives.
StorageAfterreconstitutiondivideintoaliquotsandstoreat-20ºCforahigherstABIlity.Antibodycontainsnopreservatives.Storeat4ºCwithanappropriateantibacterialagent.Usesterilemethods.HighestpurityGlycerol(1:1)maybeaddedforanadditionalstabilitywhenstoredatrefrigeratedorfreezingtemperatures.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchaseifunopened.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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