![Biosensis/Mouse monoclonal antibody to Lysosomal Associated Membrane Protein 1 [LAMP1]/M-1652-100/1 Ea](images/biosensis/M-1652-100 WB.jpg)
产品编号：M-1652-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
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商品介绍
| Description | LAMP1(LysosomalAssociatedMembraneProtein1,alsoknownasCD107a,lysosomalassociatedmembraneglycoprotein1,LGP120andLAMPA)isaproteinprimarilyassociatedwiththelysosomalmembrane.InatypicalcellLAMP1isassociatedwithsphericalvesicleslocatednexttothenucleusandthemicrotubuleorganizingcenter(1).LAMP1isfoundonthecellsurfaceoflymphocytesundergoingdegranulation,aprocessinwhichcytoplasmicvesiclesfusewiththeplasmamembrane,andthisphenomenaresultedindiscoveryofLAMP1asaCDprotein.TheLAMP1proteinhasalargeN-terminalregionwhichisinsidethelysosome,hencetopologicallyexternaltothecell,whichisoftenreferredtoasthelumenaldomain(2).Thelumenaldomainconsistsoftwohomologousglobularsegmentsseparatedbyaprolinerichsequence.Nextthereisasinglemembranespanningdomainandashort11aminoacidC-terminalcytoplasmictail.Thistailregioncontains,attheextremeC-terminus,aso-calledYXXImotifwhichisresponsIBLeforthesortingoftheintactmoleculetotheendosomeandlysozome,whereY=tyrosine,I=isoleucineandX=almostanyaminoacid(3).Thismotifisfoundinseveralotherlysosomalproteins,whereitfunctionsinthesameway.Thereare417aminoacidsinthehumanLAMP1molecule,givinganativemolecularweightof44.8kDa.HowevertheN-terminallumenalsegmentofLAMP1isveryheavilyandvariablyglycosylatedduetothepresenceof18N-linkedglycosylationsites,sothatonSDS-PAGEandonWesternblotstheproteinrunsasadiffusebandat90-120kDa.AntibodiestoLAMP1arethereforeexcellentMarkersoflysosomesinmammaliancells,thoughsomeLAMP1mayalsobeseenonlateendosomesandontheplasmamembrane. |
| Antigen | RecombinantLAMP1expressedandpurifiedfromE.coli. |
| AntibodyType | Monoclonal |
| Isotype | IgG1 |
| Clone | 6E2 |
| OtherNames | LysosomalAssociatedMembraneProtein1,alsoknownasCD107a,lysosomalassociatedmembraneglycoprotein1,LGP120andLAMPA |
| Producedin | Mouse |
| Applications | WesternBlotting(WB)andImmunocytochemistry(IC).Adilutionof1:5,000-1:10,000isrecommendedforWB.Adilutionof1:1,000-1:2,000isrecommendedforIC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Theantibodyreactswithadiffusebandat~90kDato120kDabyWesternblotonHeLacellextract.Ithasalsobeenusedsuccessfullyforimmunocytochemistry. |
| SpeciesAgainst | Human,bovine,porcine,ratandmouse.Itisexpectedthatitwillworkonothermammaltissues. |
| AntibodyAgainst | LysosomalAssociatedMembraneProtein1[LAMP1] |
| Form | LyophilizedfromPBA.Contains5%trehalose. |
| Appearance | Whitepowder |
| Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| GeneralReferences | 1.Matteoni,R.andKreiss,T.E.Translocationandclusteringofendosomesandlysosomesdependsonmicrotubules.J.CellBiol.105:1253-1265(1987).2.HoweCL,GrangerBL,HullM,GreenSA,GabelCA,HeleniusA,MellmanI.Derivedproteinsequence,oligosaccharides,andmembraneinsertionofthe120-kDalysosomalmembraneglycoprotein(lgp120):identificationofahighlyconservedfamilyoflysosomalmembraneglycoproteins.ProcNatlAcadSciUSA.85:7577-81(1988).3.RohrerJ,SchweizerA,RussellD,KornfeldS.ThetargetingofLamp1tolysosomesisdependentonthespacingofitscytoplasmictailtyrosinesortingmotifrelativetothemembrane.JCellBiol.132:565-76(1996). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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