产品编号：R-1350-100
市 场 价：¥6540.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
邮 箱：
info@ebiomall.com
商品介绍
| Description | Caspase-8isinvolvedintheprogrammedcelldeathinducedbyFasandvariousapoptoticstimuli.Manyalternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeendescribed.(Ref:EntrezGene).Recentobservationsinmicrogliahaveimplicatedcaspase8asamodulatorofmicroglialactivationinabsenceofcelldeath. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Asyntheticpeptide(DKVYQMKSKPRGYCLIINNH)correspondingtoaregion(223-242aa)fromhumanCaspase-8. |
| Sequence | DKVYQMKSKPRGYCLIINNH |
| AntibodyType | Antiserum |
| OtherNames | CASP-8;Apoptoticcysteineprotease;ApoptoticproteaseMch-5;CAP4;FADD-homologousICE/ced-3-likeprotease;FADD-likeICE;FLICE;ICE-likeapoptoticprotease5;MORT1-associatedced-3homolog;MACH;MCH5; |
| Accession | Q14790CASP8_HUMAN; |
| Producedin | Rabbit |
| Applications | WesternBlotting(WB).Aconcentrationof1.0µg/mlisrecommendedforWB.HumanCaspase-8(Isoform1precursor)hasapredictedlengthof479aminoacidsandMWof55kDa.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBagainsttheantigen. |
| AntibodyAgainst | Caspase-8 |
| Cross-reactivity | Human;rat;predictedtoreactwithmouseduetosequencehomology; |
| Blastit | Ifyouwishtousethisproductinaspeciesotherthanthosespecifiedhereandwanttodeterminetheaminoacidsequencehomologybetweentheimmunogenandthecorrespondingproteininthatspecies,simplycopytheaminoacidsequenceforthisimmunogenandtestitontheBLASTdatabasethatyoucanaccessthroughthelinkbelow.Pleasenotethatantibodiesraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptide.Whatthismeansinpractiseisthatasingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.TheBLASTdatabasecanalsobeusedtocompareanyaminoacidsequencebetweenspeciesandbetweenproteins.ThefullaminoacidsequenceofthetargetproteincanbefoundbyfollowingthelinkintheAccessionfield.YoucanthensearchanyaminoacidsequenceinthetargetproteinusingtheBLASTdatabase.Whenselectingasequencetosearch,pleasechoosecarefully,asthesequenceyouchoosemaybeaprecursorratherthanthematureproteinforexample. |
| BlastURL | Clickhere |
| Form | Lyophilisedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3 |
| Appearance | Lyophilizedwhitepowder |
| Reconstitution | Reconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial. |
| Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| GeneralReferences | 1.BurguillosM.A.Caspasesignallingcontrolsmicrogliaactivationandneurotoxicity.Nature.2011Apr21;472(7343):319-24. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
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PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
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Intracellular Trafficking
PE-1239-5
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2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
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PE-019-100
PE-1241-5
PE-003-100
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PE-1246-2
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M-1728-100
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PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
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BL-001-1250
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PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
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PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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