Description | Cyclooxygenase(COX)isanimportantenzymeintheconversionofarachidonicacidtoProstaglandinH2,theprecursoroftheseries-2prostanoids.Atleast3splicevariantshavebeenfound(COX-1,COX-2andCOX-3).COX-1isconstitutivelyexpressedinmostcelltypesandisinducedaspartoftheinflammatoryresponsebycytokinesaswellasbygrowthfactorssuchasEGFandPDGF. |
BatchNo. | Seeproductlabel. |
Unitsize | 100µg |
Antigen | Asyntheticpeptidecorrespondingtoaregion(35-52aa)fromhumanCyclooxygenase-1.Toenhancetheimmunologicalresponse,thispeptidewascoupledtocarrierproteinBSA. |
OtherNames | ProstaglandinG/Hsynthase1;Cyclooxygenase-1;COX-1;Prostaglandin-endoperoxidesynthase1;ProstaglandinH2synthase1;PGHsynthase1;PGHS-1;PHS1;PTGS1;COX1; |
Accession | P23219PGH1_HUMAN; |
Producedin | Rabbit |
Purity | Affinitypurifiedonantigencolumn |
Applications | Immunohistochemistry(IHC)andWesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanCOX-1(long)hasapredictedlengthof599residuesandMWof69kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedforIHCtodetecttheproteininformalinfixedandparaffinembeddedtissues.Heatmediatedantigenretrievalisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Cross-reactivity | Human(WB,IHC);rat(WB);mouse(WB); |
Form | Lyophilizedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3addedaspreservative |
Reconstitution | Reconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial. |
Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。