Description | Glutathioneperoxidase4(GPx-4)isinvolvedinprotectingcellsagainstmembranelipidperoxidationandcelldeath. |
Unitsize | 100µg |
Antigen | Asyntheticpeptide(VNYTQLVDLHARYAEC)correspondingtotheaminoacids78-93ofhumanglutathioneperoxidase4(IsoformMitochondrial)conjugatedtoKLHhasbeenusedastheimmunogen.Human,ratandmousesequencesareidentical. |
Sequence | VNYTQLVDLHARYAEC |
AntibodyType | Polyclonal |
OtherNames | Phospholipidhydroperoxideglutathioneperoxidase,mitochondrial;PHGPx;Glutathioneperoxidase4;GPx-4;GSHPx-4;GPX4; |
Accession | P36969GPX4_HUMAN; |
Producedin | Rabbit |
Applications | WB,IHC.TypicalworkingdilutionforIHCis1:200to1:1,000dependingontissueanddetectionmethod.ForWB,adilutionrangeof1:1,000to1:2,000isrecommended.GPx-4existsasatetramerandcanreformintomultimericcomplexesevenunderreducedconditions.ThereportedmolecularweightoftheGPx-4monomeris22kDabutisreportedtorapidlyformoligomers,thushighermolecularweightbandsgreaterthan22kDaareexpected.Mitochondrialpreparationsarealsorecommendedtoenhancesignal.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Humanandratmitochondrialglutathioneperoxidase(GPx-4) |
Cross-reactivity | Human;rat; |
BlastURL | Clickhere |
Form | Lyophilizedserumwith0.02%thimerosal |
Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。