商品介绍
| Description | FUNCTION:Involvedinredoxregulationofthecell.CanreduceH(2)O(2)andshortchainorganic,fattyacid,andphospholipidhydroperoxides.Mayplayaroleintheregulationofphospholipidturnoveraswellasinprotectionagainstoxidativeinjury. SUBUNIT:Homotetramer.SUBCELLULARLOCATION:Cytoplasm.Lysosome.Alsofoundinlungsecretoryorganelles.MISCELLANEOUS:Theactivesiteistheredox-activeCys-47oxidizedtoCys-SOH.Cys-SOHmayrapidlyreactwithaCys-SHoftheothersubunittoformanintermoleculardisulfidewithaconcomitanthomodimerformation.Theenzymemaybesubsequentlyregeneratedbyreductionofthedisulfidebythioredoxin.MISCELLANEOUS:IrreversIBLyinactivatedbyoveroxidationofCys-47(toCys-SO(3)H)uponoxidativestress.SIMILARITY:BelongstotheahpC/TSAfamily.Rehydrinsubfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | RatrecombinantPeroxiredoxin-6.Thesequenceishomologousinhumanandmouseperoxiredoxin-6. |
| OtherNames | Non-seleniumglutathioneperoxidase;antioxidantprotein2;1-Cysperoxiredoxin;1-CysPRX;Acidiccalcium-independentphospholipaseA2;NSGPx;Thiol-specificantioxidantprotein;Prdx6;Aipla2;Aop2;Tsa |
| Accession | PRDX6_RAT PRDX6_HUMAN PRDX6_MOUSE |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,WB,ELISA.ThisantibodyworkssuperblyinImmunohistochemistryonfrozenorparaffinembeddedtissues.Antigenretrievalhasbeenusedintestingbutmaynotbenecessary.Typicalworkingdilutionsforroutineimmunohistochemistryare1:100to1:1000dependingontissueanddetectionmethod.Forwesternblottingadilutionrangeof1:1000to1:4000isrecommended.Adilutionof1:1000to1:4000isrecommendedforELISA.Thisantiserumstainsthecytoplasmofepithelialcellsintheratandmouselungandratandhumanbrainastrocytes.ItstainshumanbrainastrocytesinParkinson'sandAlzheimer'sdiseaseandthecentralcoreofsomeLewybodiesinParkinson'sdiseaseanddementiawithLewybodies.Othertissueshavenotyetbeentested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThisantibodyhasbeenshowntobespecificforPeroxiredoxin-6protein. |
| Cross-reactivity | Rat,humanandmouse,otherspecieshavenotyetbeentested. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.WalshB.etal.(2010)OverexpressionofPrdx6andresistancetoperoxide-induceddeathinHepa1-6cells:Prdxsuppressionincreasesapoptosis.RedoxRep.2009;14(6):275-84. 2.GardinerF.etal.(2010)InductionofPrdx1andPrdx6inLiverCellsbySerumandTPA.IntlJ.Biol.Vol.2,No.1 |
| References | 1.KimT.-S,etal.J.Biol.Chem.272:2542-2550(1997). 2.ChoiH.-J,etal.Nat.Struct.Biol.5:400-406(1998). 3.RushJ,etal.Nat.Biotechnol.23:94-101(2005). 4.WagnerE,etal.Biochem.J.366:777-785(2002). 5.ChenJ.-W,etal.J.Biol.Chem.275:28421-28427(2000). 6.KangS.W,etal.J.Biol.Chem.273:6303-6311(1998). 7.GevaertK,etal.Nat.Biotechnol.21:566-569(2003). 8.GregoryS.G,etal.ature441:315-321(2006). 9.NagaseT,etal.DNARes.2:37-43(1995). 10.FrankS,etal.Oncogene14:915-921(1997). 11.PowerJ,etal.AmJ.Path.161:885-894(2202). 12.PowerJ,etal.ExperimentalLungRes.25:379-391(1999). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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PE-1243-50
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PE-1246-5
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S-1754-500
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PE-1239-5
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2 Plate ELISA kits
M-1763-100-FT
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PE-1242-5
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M-1728-100
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BL-001-1250
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PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
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PE-1252-100
Growth Factors
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Alzheimer\'s / Parkinson\'s
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