商品介绍
| Description | FUNCTION:DestroysrADIcalswhicharenormallyproducedwithinthecellsandwhicharetoxictoBIOLOGicalsystems.CATALYTICACTIVITY:2superoxide+2H+=O2+H2O2.COFACTOR:Binds1copperionpersubunit.COFACTOR:Binds1zincionpersubunit.SUBUNIT:Homodimer.SUBCELLULARLOCATION:Cytoplasm.DISEASE:DefectsinSOD1arethecauseoffamilialamyotrophiclateralsclerosis(FALS);alsocalledamyotrophiclateralsclerosis1(ALS1orALS).ALSisadegenerativedisorderofmotorneuronsinthecortex,brainstemandspinalcord.ALSischaracterizedbymuscularweaknessandatrophybeginninginthehandsandspreadingtotheforearmsandlegs.MusclefasciculationsarecommonlyvisIBLe.Sensoryabnormalitiesareabsent.Deathusuallyoccurswithin2to5years.ALSissometimesreferredtoasLouGehrigdiseaseafterthefamousAmericanbaseballplayerwhowasdiagnosedwiththedisorder.FALS,thefamilialformofALS,accountsforabout10%ofthecasesandistransmittedinanautosomaldominantmanner.ThemeanageatonsetofFALSis45years.MISCELLANEOUS:Zincbindingpromotesdimerization.SIMILARITY:BelongstotheCu-Znsuperoxidedismutasefamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(ASGEPVVLSGQIT)aspartofmousesuperoxidedismutase(SOD1)protein(aa:24-36)conjugatedtodiphtheriatoxoid |
| OtherNames | Superoxidedismutase[Cu-Zn];SOD1 |
| Accession | SODC_MOUSE |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | WB.Adilutionof1:500to1:1000isrecommendedforthisapplication.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Specificitywasconfirmedbywesternblotdetectingmousesuperoxidedismutase(SOD1). |
| Cross-reactivity | Thisantiserumisknowntoreactwithmouseandratsuperoxidedismutase(SOD1)protein. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| SpecificReferences | ParkKHetal.(2013)PostnatalmusclemodificationbymyogenicfactorsmodulatesneuropathologyandsurvivalinanALSmousemodel.NatCommun.2013;4:2906. |
| GeneralReferences | 1.JabuschJ.R,etal.Biochemistry19:2310-2316(1980). 2.LevanonD,etal.EMBOJ.4:77-84(1985). 3.HallewellR.A,etal.NucleicAcidsRes.13:2017-2034(1985). 4.ShermanL,etal.Proc.Natl.Acad.Sci.U.S.A.80:5465-5469(1983). 5.KajiharaJ,etal.J.Biochem.104:851-854(1988). 6.AlexanderM.D,etal.Ann.Neurol.52:680-683(2002). 7.GelleraC,etal.Neuromuscul.Disord.11:404-410(2001). 8.MurakamiT,etal.J.Neurol.Sci.189:45-47(2001). 9.PencoS,etal.Neurology53:404-406(1999). 10.MoritaM,etal.Neurosci.Lett.205:79-82(1996). 11.Bartlett,etal.J.NeuroscienceMethods.98(1):63-7(2000) |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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PE-1252-100
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