Description | SOD1bindscopperandzincionsandisoneoftwoisozymesresponsIBLefordestroyingfreesuperoxiderADIcalswhicharenormallyproducedwithinthecellsandwhicharetoxictoBIOLOGicalsystems.SOD1isasolublecytoplasmicprotein,actingasahomodimertoconvertsuperoxideradicalstomolecularoxygenandhydrogenperoxide.DefectsinSOD1arethecauseofamyotrophiclateralsclerosistype1(ALS1)whichisaneurodegenerativedisorderaffectingupperandlowermotorneuronsandresultinginfatalparalysis. |
BatchNo. | Seeproductlabel |
Unitsize | 100μL |
Antigen | RecombinanthumanSOD1 |
AntibodyType | Polyclonal |
OtherNames | Superoxidedismutase[Cu-Zn];Superoxidedismutase1;hSOD1;SOD1; |
Accession | P00441SODC_HUMAN; |
Producedin | Rabbit |
Purity | ProteinApurifiedIgG(3.5mg/mL) |
Applications | Westernblotting(1:5001:4000).Otherapplicationshavenotbeentested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Human |
Cross-reactivity | Mouse,ratpig,chicken.Otherspeciesnottested. |
BlastURL | Clickhere |
Form | Liquid.Contains0.01MPBS,pH7.4,1mg/mLBSA,20%glycerol,0.01%(w/v)sodiumazide. |
Storage | Aliquotandstoreat-20°C.Avoidrepeatedfreeze-thawcycles. |
ExpiryDate | 12monthsafterpurchase |
References | 1.JabuschJ.R,etal.Biochemistry19:2310-2316(1980). 2.LevanonD,etal.EMBOJ.4:77-84(1985). 3.Bartlett,etal.J.NeuroscienceMethods.98(1):63-7(2000). 4.AlexanderM.D,etal.Ann.Neurol.52:680-683(2002). 5.MurakamiT,etal.J.Neurol.Sci.189:45-47(2001). |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。