商品介绍
| Description | FUNCTION:Partofthehostdefensesystemofpolymorphonuclearleukocytes.ItisresponsIBLeformicrobicidalactivityagainstawiderangeoforganisms.InthestimulatedPMN,MPOcatalyzestheproductionofhypohalousacids,primarilyhypochlorousacidinphysiologicsituations,andothertoxicintermediatesthatgreatlyenhancePMNmicrobicidalactivity.MPOisanimportantMarkerformyeloidcells,fromthepromyelocytestageandtothematureforms.CATALYTICACTIVITY:Donor+H2O2=oxidizeddonor+2H2O.CATALYTICACTIVITY:Cl-+H2O2=HOCl+2H2O.COFACTOR:Binds1calciumionperheterodimer.COFACTOR:Binds1hemeB(iron-protoporphyrinIX)groupcovalentlyperheterodimer.SUBUNIT:Tetrameroftwolightchainsandtwoheavychains.SUBCELLULARLOCATION:Lysosome.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.DISEASE:DefectsinMPOarethecauseofmyeloperoxidasedeficiency(MPD).MPDisanautosomalrecessivedefectthatresultsindisseminatedcandidiasis.SIMILARITY:Belongstotheperoxidasefamily.XPOsubfamily.MicrogliaandastrocytesareknowntoexpressMPOaswell. |
| BatchNo. | Seeproductlabel |
| Unitsize | 250µg |
| Antigen | Myeloperoxidaseisolatedfromhumanpolymorphonuclearleucocytes |
| OtherNames | MPO |
| Accession | MPO_HUMAN |
| Producedin | Rabbit |
| Purity | IgG |
| Applications | IHC,WB.Adilutionof1:500-1:1000isrecommended.Thisantiserumworkssuperblyforstainingofparaffin-embeddedtissuesectionsfixedinformalin,frozensectionsandcellcytospins.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Thisantiserumreactswithhumanmyeloperoxidase. |
| Cross-reactivity | Human |
| Blastit | IfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein250µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability. |
| References | 1.ArberD.A.etal.AmJClinPathol.2001;116:25-33 2.KimuraSetal.Proteins1988;3:113-20. 3.WeilS.C.etal.Science1988;240:790-2. 4.LanzaF.JMolMed1998;76:676-81. 5.PinkusG.S.ModPathol1991;4:733-41. 6.GrayE.etal.BrainPathol.2008Jan;18(1):86-95. 7.MakiR.A.etal.JBiolChem.2009Jan30;284(5):3158-69. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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