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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg
产品编号:R-133-250
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg
商品介绍
DescriptionFUNCTION:Partofthehostdefensesystemofpolymorphonuclearleukocytes.ItisresponsIBLeformicrobicidalactivityagainstawiderangeoforganisms.InthestimulatedPMN,MPOcatalyzestheproductionofhypohalousacids,primarilyhypochlorousacidinphysiologicsituations,andothertoxicintermediatesthatgreatlyenhancePMNmicrobicidalactivity.MPOisanimportantMarkerformyeloidcells,fromthepromyelocytestageandtothematureforms.CATALYTICACTIVITY:Donor+H2O2=oxidizeddonor+2H2O.CATALYTICACTIVITY:Cl-+H2O2=HOCl+2H2O.COFACTOR:Binds1calciumionperheterodimer.COFACTOR:Binds1hemeB(iron-protoporphyrinIX)groupcovalentlyperheterodimer.SUBUNIT:Tetrameroftwolightchainsandtwoheavychains.SUBCELLULARLOCATION:Lysosome.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.DISEASE:DefectsinMPOarethecauseofmyeloperoxidasedeficiency(MPD).MPDisanautosomalrecessivedefectthatresultsindisseminatedcandidiasis.SIMILARITY:Belongstotheperoxidasefamily.XPOsubfamily.MicrogliaandastrocytesareknowntoexpressMPOaswell.
BatchNo.Seeproductlabel
Unitsize250µg
AntigenMyeloperoxidaseisolatedfromhumanpolymorphonuclearleucocytes
OtherNamesMPO
AccessionMPO_HUMAN
ProducedinRabbit
PurityIgG
ApplicationsIHC,WB.Adilutionof1:500-1:1000isrecommended.Thisantiserumworkssuperblyforstainingofparaffin-embeddedtissuesectionsfixedinformalin,frozensectionsandcellcytospins.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThisantiserumreactswithhumanmyeloperoxidase.
Cross-reactivityHuman
BlastitIfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit.
FormLyophilised
ReconstitutionReconstitutein250µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability.
References1.ArberD.A.etal.AmJClinPathol.2001;116:25-33
2.KimuraSetal.Proteins1988;3:113-20.
3.WeilS.C.etal.Science1988;240:790-2.
4.LanzaF.JMolMed1998;76:676-81.
5.PinkusG.S.ModPathol1991;4:733-41.
6.GrayE.etal.BrainPathol.2008Jan;18(1):86-95.
7.MakiR.A.etal.JBiolChem.2009Jan30;284(5):3158-69.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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