商品介绍
| Description | SOD3isamemberofthesuperoxidedismutaseproteinfamily.SODsareantioxidantenzymesthatcatalysethedismutationoftwosuperoxiderADIcalsintohydrogenperoxideandoxygen.SOD3isthoughttoprotectthebrain,lungsandothertissuesfromoxidativestress.Itissecretedintotheextracellularspaceandformsaglycosylatedhomotetramerthatisanchoredtotheextracellularmatrixandcellsurfacesthroughaninteractionwithheparansulfateproteoglycanandcollagen.AsmallpercentageofSOD3iscleavedneartheC-terminusbeforesecretiontogeneratecirculatingtetramersthatdonotinteractwiththeextracellularmatrix. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(WTGEDSAEPNSDSAEWIRD)correspondingtotheaminoacids18-37ofhumanextracellularsuperoxidedismutaseconjugatedtodiphtheriatoxinhasbeenusedastheimmunogen. |
| OtherNames | EC-SOD;SOD3 |
| Accession | SODE_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,WB.ThisantibodyworkssuperblyinImmunohistochemistryonfrozenorparaffinembeddedtissues.Antigenretrievalhasbeenusedintestingbutmaynotbenecessary.Typicalworkingdilutionsforroutineimmunohistochemistryare1:100to1:2000dependingontissueanddetectionmethod.Forwesternblottingadilutionrangeof1:1000to1:4000isrecommended.Thisantibodystainsprominentlyspecifichumanairway(probablyClaracells)andalveolartypeIIcellsandsometubularcellsinthekidney.Othertissueshavenotyetbeentestedbutthegeneexpressionhasalsobeenreportedinheart,pancreasandplacenta.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Thisantibodyhasbeenshowntobespecificforextracellularsuperoxidedismutaseprotein. |
| Cross-reactivity | Human |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.HjalmarssonK,etal.Proc.Natl.Acad.Sci.U.S.A.84:6340-6344(1987). 2.FolzR.J,etal.Genomics22:162-171(1994). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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