产品编号：C-1691-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
邮 箱：
info@ebiomall.com
商品介绍
| Description | FUNCTION:PromotesmicrotubuleassemblyandstABIlity,andmightbeinvolvedintheestablishmentandmaintenanceofneuronalpolarity.TheC-terminusbindsaxonalmicrotubuleswhiletheN-terminusbindsneuralplasmamembranecomponents,suggestingthattaufunctionsasalinkerproteinbetweenboth.Axonalpolarityispredeterminedbytaulocalization(intheneuronalcell)inthedomainofthecellbodydefinedbythecentrosome.TheshortisoformsallowplasticityoftheCytoskeletonwhereasthelongerisoformsmaypreferentiallyplayaroleinitsstabilization. SUBCELLULARLOCATION:Cytoplasm;cytosol.Cellmembrane.Mostlyfoundintheaxonsofneurons,inthecytosolandinassociationwithplasmamembranecomponents.ALTERNATIVEPRODUCTS:8namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.Isoformsdifferfromeachotherbythepresenceorabsenceofupto5ofthe15exons.Oneoftheseoptionalexonscontainstheadditionaltau/MAPrepeat.TISSUESPECIFICITY:Expressedinneurons.IsoformPNS-tauisexpressedintheperipheralnervoussystemwhiletheothersareexpressedinthecentralnervoussystem.DEVELOPMENTALSTAGE:Four-repeat(typeII)tauisexpressedinanadult-specificmannerandisnotfoundinfetalbrain,whereasthree-repeat(typeI)tauisfoundinbothadultandfetalbrain.DOMAIN:Thetau/MAPrepeatbindstotubulin.InAlzheimerdisease,theneuronalcytoskeletoninthebrainisprogressivelydisruptedandreplacedbytanglesofpairedhelicalfilaments andstraightfilaments,mainlycomposedofhyperphosphorylatedformsofMicrotubule-associatedproteinTau.DefectsinMicrotubule-associatedproteinTauareacauseoffrontotemporaldementiaandparkinsonismlinkedtochromosome17,aswellasanumberofotherneurodegenerativediseases. |
| BatchNo. | Seeproductlabel. |
| Unitsize | 100µL |
| Antigen | RecombinantfulllengthversionoftheshortesthumantauisoformpurifiedfromE.coli. |
| AntibodyType | Polyclonal |
| Isotype | AntibodyissuppliedasanaliquotofconcentratedIgYpreparation. |
| OtherNames | Neurofibrillarytangleprotein;Pairedhelicalfilament-tau;PHF-tau;MAPT;MTBT1;TAU |
| Accession | P10636TAU_HUMAN |
| Producedin | Chicken |
| Purity | IgY |
| Applications | WesternBlotting(WB)andImmunocytochemistry(IC).Adilutionof1:5,000-1:10,000isrecommendedforWB.Adilutionof1:500-1,000isrecommendedforIC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Theantibodyreactswithmultiplecloselyspacedbandscoveringtheregionoftheblotfrom48kDato67kDa,withanadditionalbandat100kDa.Ithasalsobeenusedsuccessfullyforimmunocytochemistry. |
| SpeciesAgainst | Human. |
| Cross-reactivity | Expectedtoreactwithhorse,cow,pig,chicken,ratandmouse. |
| Form | Lyophilizedwith3%trehalose,withoutpreservatives. |
| Reconstitution | Reconstitutewith100µLsterile-filtered,ultrapurewater.Centrifugebrieflytoremoveanyinsolublematerial. |
| Storage | Storelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°Cto-80°Cforahigherstability.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase(unopenedvial). |
| GeneralReferences | SkeneJH,WillardM.Changesinaxonallytransportedproteinsduringaxonregenerationintoadretinalganglioncells.J.CellBiol.89:86-95(1981). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
Other Neuronal
Neuropeptides & Receptors
PE-1242-5
TR-200-BG
B-200-PS
BL-003-1000
Neuronal Markers
Apoptosis
Receptors & Channel Molecules
Alzheimer\'s / Parkinson\'s
S-1754-500
2 Plate ELISA kits
PE-1239-2
1 Plate ELISA kits
Signalling & Transcription
Diabetes & Obesity
Development
PE-1242-2
PE-019-100
Stem Cells
M-1763-100-FT
M-1728-100
BL-005-500
Neurotrophic Factors
Antioxidant Enzymes
Neurotransmitters & Enzymes
PE-1246-2
Neuroendocrine
PE-1246-5
Antibody Kits
PE-1606-100
PE-1253-100
M-1249-100
TR-300-AG
Sensory Nervous System
TR-100-BG
PE-1608-5
TR-100-FJT
Cancer
Autophagy
Intracellular Trafficking
Neurotrophic Factor Receptors
B-100-PS
PE-1241-5
TR-400-AG
BL-004-500
PE-1762-100
PE-019-500
BL-002-1250
Cell Cycle Regulators
Receptor Body Chimeras
Matrix & Adhesion Molecules
PE-003-100
PE-1239-5
Tag Antibodies
DNA Damage & Repair
PE-1608-1
PE-019-25
PE-1608-10
PE-1243-25
S-1759-100
TR-200-BGT
PE-1243-50
PE-001-100
Junction Proteins
Growth Factors
Cell Markers
TR-100-FJ
PE-1252-100
BL-001-1250
销售排行
![Biosensis/Mouse monoclonal antibody to human BAI2 [6A12]: IgG/M-804-100/100 µg](images/biosensis/201712/H00000576-M01-WB-recprtn.jpg)
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