商品介绍
| Description | NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family. |
| Batch No. | See product label |
| Unit size | 100 µl |
| Antigen | Recombinant human NT3 |
| Other Names | Neurotrophin-3; Neurotrophic factor; HDNF; Nerve growth factor 2; NGF-2; Ntf3; Ntf-3 |
| Accession | NT3_HUMAN |
| Produced in | Sheep |
| Purity | Whole serum |
| Applications | IHC, ELISA, WB, dot blot, inhibition of biological activity. A dilution of 1:200 to 1:2000 is recommended for IHC, ELISA and western blot. For inhibition of biological activity: 1:10-50 for in vitro, 5-10 µl/g body weight for in vivo. Biosensis recommends optimal dilutions/concentrations should be determined by the end user. |
| Specificity | A cross reactivity of less than 1% to mouse NGF, recombinant human BDNF and 5% to NT4/5 has been shown by 1-site ELISA. |
| Cross-reactivity | This antiserum is known to react with rat, chicken and human NT3. |
| Blast it | If you would like to see the shared identity between different species or other proteins follow the link in Accession field, select then the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it. |
| Form | Lyophilised |
| Reconstitution | Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage | After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles. |
| Expiry Date | 12 months after purchase |
| References | 1. Zouh et al. (1996) Mol. Neurobio. 13(3): 185-97
2. Rush et al. (1997) Clin. Exp. Pharmacol. 24: 549-55 3. Tafreshi et al. (1998) Neurosci. 83(2): 373-80 |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
Sensory Nervous System
PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
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PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
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Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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