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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Leucine-Rich Repeat Kinase 2 inhibitor LRRK2-IN-1 (5mg)/PE-1608-5/5mg
产品编号:PE-1608-5
市  场 价:¥5340.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
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美  元  价:$267.00
品      牌: Biosensis
公      司:Biosensis
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Biosensis/Leucine-Rich Repeat Kinase 2 inhibitor LRRK2-IN-1 (5mg)/PE-1608-5/5mg
商品介绍
DescriptionLeucine-RichRepeatKinase2(LRRK2)isamemberoftheleucine-richrepeatkinasefamily.MutationsintheLRRK2genehavebeenlinkedwithlate-onsetautosomaldominantParkinson’sdisease(PD).ArecentscreeningidentifiedtheanalogLRRK2-IN-1asapotentandselectiveinhibitorofLRRK2.ThisresearchbyDengetal(2011,NatChemBiol)showedthatLRRK2-IN-1suppressedLRRK2kinaseactivityinvivoleADIngtodephosphorylationofSer910/Ser935,lossof14-3-3bindingandaccumulationofLRRK2withinaggregratefibrillarstructures.LRRK2-IN-1,isthefirstselectiveandpotentinhibitorofLRRK2.LRRK2-IN-1inhibitsbothwild-typeandG2019SmutantLRRK2kinaseactivitywithIC50valuesof13nMand6nMrespectively(Dengetal2011,NatChemBiol).
RelatedproductsLeucine-RichRepeatKinase2inhibitorLRRK2-IN-1(10mg)
BatchNo.Seeproductlabel
Unitsize5mg
OtherNamesProtein:Leucine-richrepeatserine/threonine-proteinkinase2;Dardarin;LRRK2;PARK8
AccessionQ5S007LRRK2_HUMAN;
MolecularWeight570.69g
CompoundName2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Purity>97%byHPLC
Biol.activityLRRK2-IN-1inhibitsbothwild-typeandG2019SmutantLRRK2kinaseactivitywithIC50valuesof13nMand6nMrespectively(Dengetal2011,NatChemBiol).
ApplicationsBiosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
AppearanceDrypowder
StorageStoredry,unopenedvialprotectedfromlightforupto3monthsatRTorat-70ºCforupto1year.Reconstituteproductin100%ACSgradeDMSOandstoreat-80ºC,inaliquots,protectedfromlight,forupto1month.Preventmultiplefreeze-thawcycles.CASNumber1234480-84-2.
ExpiryDateSeestorageconditions
SpecificReferences1.DengX.etal(2011)CharacterizationofaselectiveinhibitoroftheParkinson"sdiseasekinaseLRRK2NatChemBiol.2011Apr;7(4):203-5.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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