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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Mouse p75NTR Nerve Growth Factor Receptor-Fc Chimera expressed in mammalian cells/PE-1704-25/25 µg
产品编号:PE-1704-25
市  场 价:¥4340.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$217.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Mouse p75NTR Nerve Growth Factor Receptor-Fc Chimera expressed in mammalian cells/PE-1704-25/25 µg
商品介绍
DescriptionNervegrowthfactor(NGF)receptor,alsoknownasp75NTR,isalowaffinityNGFreceptor.ItbindswithequalaffinityallmembersoftheneurotrophinfamilyincludingbetaNGF,BDNF,NT-3andNT-4/5.Italsobindsthepro-neurotrophins.NGFreceptorsmediatesignalingofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.ThesereceptorsarealsothoughttoplayaroleinneurogenerativediseasessuchasAlzheimersdisease.Thep75NTRNGFreceptorisatypeItransmembraneglycoprotein(396aa)consistingofasignalpeptide(21aa),anextracellulardomain(225aa)whichcontainsfourcysteinerichdomainsresponsIBLeforligandbinding,atransmembranedomain(19aa)andacytoplasmicdomain(152aa).ItisamemberoftheTNF-alphareceptorfamily(TNR16).Recently,p75NTRhasbeenshowntoactasareceptorformanypathogenssuchasprions,rABIesvirusandamyloidbeta.Italsoactsasaco-receptorforNOGO,mediatinginhibitorysignalsofmyelinassociatedprotein.
BatchNo.Seeproductlabel
Unitsize25µg
OtherNamesLow-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;p75NTR;CD271;FastNGFreceptor.
AccessionQ9Z0W1TNR16_MOUSE;
ProducedinMammalian(CHO)cells.ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanNGFreceptor(aminoacids1-224)wasfusedtotheFcregionofhumanIgG1(aminoacids104-330).ThechimericproteinwasexpressedinmodifiedCHOcells.Thefullsequenceisavailableonrequestfrombiospeak@Biosensis.com.
MolecularWeightTheNGFReceptor-Fcchimeramigratesasabroadbandbetween65and115kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedNGFReceptor-Fcchimerahasapredictedmassof49.7kDa.TheunmodifiedNGFReceptor-FcchimerahasapredictedpIof4.92.
Purity>95%,asdeterminedbySDS-PAGE.
FormFreeze-dried.
ReconstitutionItisrecommendedthat0.25mlofsterilephosphate-bufferedsaline(PBS)beaddedtothevial.
StorageLyophilizedproductsshouldbestoredat2-8°C.Followingreconstitution,short-termstorageat4°Cisrecommendedandlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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