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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Human TrkC-Fc Chimera expressed in mammalian cells/PE-1236-50/50 µg
产品编号:PE-1236-50
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Human TrkC-Fc Chimera expressed in mammalian cells/PE-1236-50/50 µg
商品介绍
DescriptionTrkCisamemberofthetropomyosin-relatedkinasereceptorfamily.TrkCisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkCisthereceptorforneurotrophin-3(NT-3).SignallingthroughTrkCleadstocelldifferentiationandmayplayaroleinthedevelopmentofproprioceptiveneuronsthatsensebodyposition.TrkCisaheavilyglycosylatedmoleculewith13potentialN-linkedglycosylationsiteswithintheextracellulardomain. 
BatchNo.Seeproductlabel
Unitsize50µg
OtherNamesTropomyosin-relatedkinasereceptor;NT-3growthfactorreceptor;Neurotrophictyrosinekinasereceptortype3;TrkCtyrosinekinase;GP145-TrkC;Trk-C;NTRK3;TRKC;TrkC-FcChimera
AccessionQ16288NTRK3_HUMAN;
ProducedinHuman-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanTrkC(aminoacids1-428)wasfusedtotheFcregionofhumanIgG1(aminoacids93-330).Thechimericproteinwasexpressedinmodifiedhuman293cells.
MolecularWeightTheTrkC-Fcchimeramigratesasabroadbandbetween85and150kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedTrkC–Fcchimerahasapredictedmolecularmassof71.9kDa.TheTrkC-FcchimeraseparatesintoanumberofisoformswithapIbetween4and7in2DPAGE.TheunmodifiedTrkC–FcchimerahasapredictedpIof5.8.
Purity>95%,asdeterminedbySDS-PAGEandvisualizedbysilverstain.
FormTheTrkC-Fcchimeraconsistsof15-55%carbohydratebyweight.Whenreconstitutedin0.5mlsterilephosphate-bufferedsaline,thesolutionwillcontain1%humanserumalbumin(HSA)and10%trehalose.
ReconstitutionItisrecommendedthat0.5mlofsterilephosphate-bufferedsalinebeaddedtothevial.
StorageLyophilizedproductsshouldbestoredat2to8°C.Followingreconstitutionshort-termstorageat4°Cisrecommended,andlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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