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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells/PE-1237-15/15 µg
产品编号:PE-1237-15
市  场 价:¥3740.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$187.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Human Nerve Growth Factor Receptor-Fc Chimera (209 amino acids) expressed in mammalian cells/PE-1237-15/15 µg
商品介绍
DescriptionNervegrowthfactor(NGF)receptor,alsoknownasp75NTR, isalowaffinityNGFreceptor.ItbindswithequalaffinityneurotrophinssuchasbetaNGF,BDNF,NT-3andNT-4.NGFreceptorsmediatesignalingofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.ThesereceptorsarealsothoughttoplayaroleinneurogenerativediseasessuchasAlzheimersdisease.TheNGFreceptorisatypeItransmembraneglycoprotein(399aa)consistingofasignalpeptide(28aa),anextracellulardomain(222aa)whichcontainsfourcysteinerichdomainsresponsIBLeforligandbinding,atransmembranedomain(22aa)andacytoplasmicdomain(155aa).
BatchNo.Seeproductlabel
Unitsize15µg
OtherNamesLow-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;p75NTR;CD271;
AccessionP08138TNR16_HUMAN;
ProducedinHuman-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanNGFreceptor(aminoacids1-237)wasfusedtotheFcregionofhumanIgG1(aminoacids93-330).Thechimericproteinwasexpressedinmodifiedhuman293cells.
MolecularWeightTheNGFReceptor-Fcchimeramigratesasabroadbandbetween65and90kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedNGFReceptor-Fcchimerahasapredictedmassof49.2kDa.TheNGFReceptor-FcchimeraseparatesintoanumberofisoformswithapIbetween4.2and5.3in2DPAGE.TheunmodifiedNGFReceptor-FcchimerahasapredictedpIof4.89.
Purity>95%,asdeterminedbySDS-PAGEandvisualizedbysilverstain
FormTheNGFReceptor-Fcchimeraconsistsof25-45%carbohydratebyweight.
ReconstitutionItisrecommendedthat0.5mlofsterilephosphate-bufferedsaline(PBS)beaddedtothevial.Whenreconstitutedin0.5mlofPBS,thesolutionwillcontain1%humanserumalbumin(HSA)and10%trehalose.
StorageLyophilizedproductsshouldbestoredat2-8°C.Followingreconstitution,short-termstorageat4°Cisrecommendedandlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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