产品编号：BEK-2219-2P
市 场 价：¥15340.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
邮 箱：
info@ebiomall.com
商品介绍
Finda1platesizeofthisproducthere.Enquireaboutbulkdiscountsfortenormoreplates,atsales@Biosensis.com| Description | TheBiosensisNGFR/p75ECDRapidTMenzyme-linkedimmunosorbentassay(ELISA)KitisasandwichELISAthatallowsthequantificationoftheextracellulardomain(ECD)ofhumanp75neurotrophinreceptorinlessthan4hoursinurine,serum,citrate-plasma,CSFandcellculturesupernatantsonlyifusedasdirected.Pleaserefertothekitprotocolforspecificuseinstructionsforeachsubstrateapplication. | Notethatcaptureanddetectionantibodieshavebeenoptimizedforincreasedassaysensitivity,andreagentsfrompreviouslotsshouldnotbeused.Thisoptimizedhumanp75ECDELISAassaydemonstratesanincreasedsensitivity,loweringtheLODabout8-foldtothepreviousassayversion.ItrepresentsthemostsensitiveNGFR/p75ECDELISAassayavailabletoday,withadetectionlimitofatleast6pg/mL,andaquantificationrangeof7.8-500pg/mL. ThisELISAkitconsistsofapre-coatedmousemonoclonalanti-p75ECDcaptureantibody,abiotinylatedmousemonoclonalanti-p75ECDdetectionantibodyandhorserADIshperoxidase(HRP)-conjugatedstreptavidin.Theadditionofasubstrate(3,3,5,5-tetramethylbenzidine,TMB)yieldsacoloredreactionproductwhichisdirectlyproportionaltotheconcentrationofp75ECDpresentinsamplesandproteinstandards.Ahumanp75ECDpositivecontrol(QCsample)isprovidedtoassureconsistentassayperformance. ThisNGFR/p75ECDELISAkitemploysanin-houserecombinanthumanp75ECD-Fcchimeraasstandardthathasbeenvalidatedagainstanexternallyavailablep75ECD-Fcprotein.Whilethereisacurrentlackofacommerciallyavailable,truehumanp75ECDstandard,thisELISAkitallowsquantificationofhumanp75ECDasp75ECD-Fchumanequivalents.PleasenotethattheantibodiesusedinthisELISAdonotcross-reactwithmousep75ECD. Note1:Forresearchuseonly.Notfordiagnosticandclinicalpurposes. Note2:ThisELISAshouldnotbeconfusedwiththatreportedinthePLoSONEpublicationbyShepheardetal(2014,2017)oranyotherassay.Thiskitisuniqueandhasbeendeveloped,manufacturedandextensivelyvalidatedin-houseandisthemostsensitiveELISAavailableforthedetectionofp75NTR-ECDinhumansamples. Relatedproducts | BEK-2220-2P,MouseNGFR/p75ECDRapidTMELISA | BL-002-1250,HeterophilicantibodyblockerforELISAassaysutilizingmouseantibodies BatchNo. | Refertotheproductlabel. | Antigen | Thenervegrowthfactor(NGF)receptor(NGFR),alsoknownasp75neurotrophinreceptor(p75NTR;TNFRS16;CD271)isacommonreceptorfortheneurotrophinsNGF,BDNF,NT-3andNT-4/5.Inneurons,p75NTRmediatesavarietyofphysiologicalfunctionsincludingsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Apotentialpathologicalroleforp75NTRhasbecomeevidentinrecentyears.Alteredp75NTRexpressionlevelsareimplicatedindegenerationofspinalmotorneuronsinhumanandmousemodelsofamyotrophiclateralsclerosis(ALS).Importantly,theextracellulardomainofp75NTR(p75ECD)isshedfromthecellmembraneandexcretedinurine.Recentfindingsfurthersuggestthatp75ECDcouldbeanearlybioMarkerforALSinhumans,assignificantlyelevatedp75ECDlevelsarefoundinurineofALSpatientsascomparedtohealthycontrols. | OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;Tumornecrosisfactorreceptorsuperfamilymember16;CD271;NGFR;TNFRSF16. | Accession | TNR16_HUMAN | Specificity | Human. | Cross-reactivity | ThisELISAkitdoesnotcross-reactwithmousep75ECDprotein. | Storage | Storeat2-8°C. | ExpiryDate | 12monthsfrompurchase. | References | ThefollowingreferencesgiveageneralbackgroundonthesuitABIlityofp75ECDasabiomarkerforALSdiseaseprogression. | Shepheardetal.(2017)Neurology2017Feb22.doi:10.1212/WNL.0000000000003741.[Epubaheadofprint]. Shepheardetal.(2014)PLoSONE9(1):e87398.doi:10.1371/journal.pone.0087398. DiStefano&Johnson(1988)ProcNatlAcadSciUSA85:270-274. Kitcomponents | TheELISAkitboxcontains2x96pre-coatedstripplates,proteinstandards,QCsample,detectionreagents,heterophilicantibodyblocker,washandsamplebuffersanddetailedprotocols. | Range | 7.8-500pg/mL | Sensitivity | Typicallimitofdetection(LOD)forhumanp75ECDislessthan6pg/mL,determinedas150%oftheblankvalue. | Kitprotocol |  BEK-2219_as_at_Sep2017.pdfMSDS | MSDS_Rapid_ELISA_as_at_Aug2017.pdf品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。 公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
Sensory Nervous System
PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
Cell Markers
PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
Other Neuronal
Neurotransmitters & Enzymes
Antioxidant Enzymes
Neuronal Markers
Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
销售排行
厂家直采
全球直采 正品优价
正品保障
厂家直发 有线跟踪
正规清关
CIF100%正规报关，提供发票
及时交付
限时必达 不达必赔
总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏ 0512-67156496（苏州）
版权信息：
© 2015- 苏州蚂蚁淘生物科技有限公司 版权所有 中国
友情链接：
联系QQ:764052152
免责声明：
本站有部分内容来自互联网，如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权，请来电或致函告之，
本网站将在规定时间内给予删除等相关处理。 
扫描二维码关注官方微信
获取最新促销及产品信息
|
