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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit polyclonal antibody to Growth Associated Protein 43 (GAP43, 217-227): Affinity Purified/R-1651-100/1 Ea
产品编号:R-1651-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit polyclonal antibody to Growth Associated Protein 43 (GAP43, 217-227): Affinity Purified/R-1651-100/1 Ea
商品介绍
DescriptionGAP43isveryabundantproteinwhichisfoundconcentratedinneurons.Onegroupdiscovereditasoneofthreeproteinswhichbecomesunregulatedduringtheregenerationofthetoadopticnerve(1).ThreeGAPs(Growthassociatedproteins)werediscovered,andthenumber43comesfromtheapparentSDS-PAGEmolecularweightoftheonenamedGAP43.TheHGNCnameforthisproteinis,notsurprisingly,GAP43.LaterworkshowedthatGAP43doesnotrunonSDS-PAGEinafashionwhichaccuratelyreflectsitsmolecularweight,andthatGAP43proteinsfromdifferentspeciesmayrunatdifferentapparentmolecularweights.PartlyduetothesefeaturesGAP43wereindependentlydiscoveredbyseveraldifferentgroupsandthereforehasseveralalternatenames,suchasproteinF1,pp46,neuromodulin,neuralphosphoproteinB-50andcalmodulin-bindingproteinP-57.IneachcasethenumberreflectstheapparentSDS-PAGEmolecularweight,andunderlinestheunusualpropertiesofthismolecule.MammalianGAP43proteinscontainsonly226-243aminoacids,andsotherealmolecularweightis23.61-25.14kDa.GAP43hasbeenextensivelystudiedandisknowntobeamajorproteinkinaseCsubstrateandtobindcalmodulinavidly.GAP43isanchoredtotheplasmamembranebypalmitoylationmodifications.
AntigenC-terminalpeptide217-227ofratandmouseGAP43,whichisKEDPEADQEHA,towhichanNterminalCysteineresiduewasaddedtoallowchemicalcouplingtoKeyholeLimpetHemocyanincarrierprotein.
AntibodyTypePolyclonal
IsotypeIgG
AccessionP07936NEUM_RAT
P06837NEUM_MOUSE
ProducedinRabbit
PurityAffinitypurified.
ApplicationsWesternBlotting(WB).Adilutionof1:5,000-1:20,000isrecommended.Adilutionof1:500-2,000isrecommendedforICC/IHC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityTheantibodyreactswitha43kDabandbyWesternblotonbovinecerebellumhomogenate.Themolecularweightoftheproteinrecognizedcanvary(~43-57kDa)dependingonthespeciesandthepercentageacrylamideusedintheSDS-PAGEgel.Ithasalsobeenusedsuccessfullyforimmunocytochemistry.
SpeciesAgainstHuman,ratandbovine.Itisexpectedthatitwillworkonothermammaltissuesduetoaminoacidsequencesimilarity.
AntibodyAgainstGrowthAssociatedProtein43(GAP43)
FormLyophilisedfromPBS,pH7.4containing3%trehalose,withoutpreservatives.
ReconstitutionReconstitutewith100µLsterile-filtered,ultrapurewater,toachieveanantibodyconcentrationof1mg/mL.Centrifugebrieflytoremoveanyinsolublematerial.
StorageStorelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°Cto-80°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase(unopenedvial).
GeneralReferencesSkeneJH,WillardM.Changesinaxonallytransportedproteinsduringaxonregenerationintoadretinalganglioncells.J.CellBiol.89:86-95(1981).
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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