![Biosensis/Mouse monoclonal antibody to Myelin Basic Protein [7G7]/M-1384-50/50 µl](images/biosensis/201712/M-1384-50-IHC-450x360.jpg)
商品介绍
| Description | Myelinisamembranecharacteristicofthenervoustissueandfunctionsasaninsulatortoincreasethevelocityofthestimulibeingtransmittedbetweenanervecellbodyanditstarget.Myelinisolatedfromhumanandbovinenervoustissueiscomposedofapproximately80%lipidand20%protein,and30%oftheproteinfractionconstitutesmyelinbasicprotein(MBP).MBPisan"intrinsicallyunstructured"proteinwithahighproportion(approximately75%)ofrandomcoil,butpostulatedtohavecoreelementsofbeta-sheetandalpha-helix.MBPisamajorproteininCNSmyelinandisexpressedspecificallyinthenervoussystem.AdetailedimmunochemicalexaminationofmonoclonalandpolyclonalantibodyresponsestoMBPanditspeptideshasrevealedtheexistenceofasmanyas27antigenicdeterminants,manyofthemconformational.TopologicalmappingofthepotentialantigenicdeterminantsontoamodelofMBPsecondarystructureplacesthesedeterminantswithin11separateregionsofthemolecule,includingthoseportionsthathavebeenfoundtobeencephalitogenic.Themessageformyelinbasicproteinisselectivelytranslocatedtotheendsofthecellprocesses.Immunizationwithmyelin-associatedantigensincludingMBPsignificantlypromotesrecoveryafterspinalcordcontusioninjuryintheratmodel.FUNCTION:Is,withPLP,themostabundantproteincomponentofthemyelinmembraneintheCNS.HasaroleinboththeformationandstABIlizationofthiscompactmultilayerarrangementofbilayers.Eachsplicevariantandchargeisomermayhaveaspecializedfunctionintheassemblyofanoptimized,biochemicallyfunctionalmyelinmembrane(Bysimilarity).SUBUNIT:Homodimer(Bysimilarity).SUBCELLULARLOCATION:Myelinmembrane;peripheralmembraneprotein;cytoplasmicside.Cytoplasmicsideofmyelin.TISSUESPECIFICITY:Foundinboththecentralandtheperipheralnervoussystem. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µl |
| Antigen | ThreepeptidesequencesconservedinhigherverterbrateMBPprotein. |
| AntibodyType | Monoclonal |
| Isotype | IgG |
| Clone | 7G7 |
| OtherNames | MyelinBasicProtein;MyelinA1protein;Myelinmembraneencephalitogenicprotein;MBP; |
| Accession | P02686MBP_HUMAN; |
| Producedin | Mouse |
| Applications | WesternBlotting(WB),Immunocytochemistry(IC),Immunohistochemistry(IH)andFlowCytometry(~2µgper10^6cells).TherecommendeddilutionforWBis1:5,000-10,0000and1:500-1,000forICandIH.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWB.Thisantibodystainsbandsaround21.5kDaand18.5kDa.Asuitablecontroltissueisratspinalcordorperipheralnervehomogenate.ThemajorisoformsofMBPrunasacloselyspaceddoubleof22kDaand18kDa. |
| AntibodyAgainst | MyelinBasicProtein |
| Cross-reactivity | Human,Rat |
| BlastURL | Clickhere |
| Form | Lyophilisedwith5%trehalose |
| Appearance | Whitepowder |
| Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°Cforahigherstability.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.Schwartz,etal.,ProgBrainRes137,401-6(2002) 2.Hauben,etal.,JClinInvest108,591-9(Aug,2001) 3.Yoles,etal.,JNeurosci21,3740-8(Jun1,2001) 4.Hauben,etal.,JNeurosci20,6421-30(Sep1,2000) 5.Harauz,etal.,Nature389,783-4(1997).Micron35,503-42(2004) 6.Givogri,etal.,JNeurosciRes59,153-9(Jan15,2000) 7.Kim,etal.,IntJBiochemCellBiol29,743-51(May,1997) 8.Kalwy,etal.,MolMembrBiol11,67-78(Apr-Jun,1994) 9.Wajgt,etal.,ActaNeurolScand68,337-43(Nov,1983) 10.Day,etal.,JNeuroimmunol10,289-312(Feb,1986) 11.Mikoshiba,etal.,CompBiochemPhysiolC98,51-61(1991) 12.Brophy,etal.,TrendsNeurosci16,515-21(Dec,1993) 13.Matsuo,A.etal.(1997)Am.J.Pathol.150(4):1253-1266 |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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