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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit antibody to ATG4B (APG4B): whole serum/R-157-100/100 µl
产品编号:R-157-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit antibody to ATG4B (APG4B): whole serum/R-157-100/100 µl
商品介绍
DescriptionFUNCTION:Cysteineproteaserequiredforautophagy,whichcleavestheC-terminalpartofeitherMAP1LC3,GABARAPL2orGABARAP,allowingtheliberationofformI.AsubpopulationofformIissubsequentlyconvertedtoasmallerform(formII).FormII,witharevealedC-terminalglycine,isconsideredtobethephosphatidylethanolamine(PE)-conjugatedform,andhasthecapacityforthebindingtoautophagosomes.ENZYMEREGULATION:InhibitedbyN-ethylmaleimide.SUBCELLULARLOCATION:Cytoplasm(Probable).ALTERNATIVEPRODUCTS:5namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Mainlyexpressedintheskeletalmuscle,followedbybrain,heart,liverandpancreas.SIMILARITY:BelongstothepeptidaseC54family.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(CLERFFDSEDED)correspondingtotheC-terminusofhumanATG4BproteinconjugatedtoBlueCarrierProteinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromofATG4Bproteininmouseandrat.
OtherNamesCysteineproteaseATG4B;Autophagy-relatedprotein4homologB;hAPG4B;Autophagin-1;Autophagy-relatedcysteineendopeptidase1;AUT-like1cysteineendopeptidase;ATG4B;APG4B;AUTL1;KIAA0943;
AccessionATG4B_HUMAN
ATG4B_MOUSE
ATG4B_RAT
ProducedinRabbit
PurityWholeserum
ApplicationsIHC,immunofluorescence,WB.Adilutionof1:100to1:2000dilutionisrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityIHC,WBandELISAconfirmedthespecificityforATG4B.
Cross-reactivityHuman,rat.Otherspeciesnotyettested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDateSixmonthsafterpurchase
SpecificReferences1.A.J.Smuderetal(2011)Exerciseprotectsagainstdoxorubicin-inducedMarkersofautophagysignalinginskeletalmuscle.JApplPhysiol.2011Jul21
References1.MarinoG,etal.J.Biol.Chem.278:3671-3678(2003).
2.KabeyaY,etal.J.CellSci.117:2805-2812(2004).
3.NagaseT,etal.DNARes.6:63-70(1999).
4.OtaT,etal.Nat.Genet.36:40-45(2004).
5.SugawaraK,etal.J.Biol.Chem.280:40058-40065(2005).
6.KumanomidouT,etal.J.Mol.Biol.355:612-618(2006).
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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