Description | ATG10playsaroleinautophagy.ItisanE2-likeenzymeinvolvedin2ubiquitin-likemodificationsessentialforautophagosomeformation:ATG12-ATG5conjugationsandmodificatioonofasolubleformofMAPLC31A,ahomologofyeastATG8,toamembraneboundform. ItisalsoabletodirectlyinteracteitherwithATG5orATG7. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | Apeptide(CLKNSQKINKNV)correspondingtotheC-terminalofhumanATG10proteinhasbeenusedastheimmunogen. |
OtherNames | Autophagy-relatedprotein10;APG10-like;ATG10 |
Accession | ATG10_HUMAN |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | IHC,immunofluorescence.Adilutionof1:100to1:1000dilutionisrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | IHC,WBandELISAconfirmedthespecificityforATG10. |
Cross-reactivity | Human.Otherspeciesnotyettested. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsatminus20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | Sixmonthsafterpurchase |
SpecificReferences | 1.RyningenAetal(2012)InhibitionofMammaliantargetofrapamycininhumanacutemyeloidleukemiacellshasdiverseeffectsthatdependontheenvironmentalinvitrostress.BoneMarrowRes.2012;2012:329061. |
References | 1.WanD.etal.Proc.Natl.Acad.Sci.U.S.A.101:15724-15729(2004) 2.OtaT.etal.Nat.Genet.36:40-45(2004) 3.TheMGCProjectTeam.GenomeRes.14:2121-2127(2004). |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。