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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit polyclonal to Lamin A/C/R-1697-100/100 uL
产品编号:R-1697-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>多克隆抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit polyclonal to Lamin A/C/R-1697-100/100 uL
商品介绍
DescriptionTheLaminproteinsaremembersoftheintermediatefilamentproteinfamilybutarelocatedinsidethenucleusratherthaninthecytoplasm(1).Thelaminsfunctionasskeletalcomponentstightlyassociatedwiththeinnernuclearmembrane.OriginallytheproteinsofthenuclearCytoskeletonwerenamedLaminA,BandC,fromtoptobottomasvisualizedonSDS-PAGEgels.SubsequentlyitwasfoundthatLaminsAandCwerecodedforbyasinglegene(2),whiletheLaminBbandmaycontaintwoproteinsencodedbytwogenesnowcalledLaminB1andLaminB2.LaminAhasamassofabout74kDawhileLaminCis65kDa.TheLaminAproteinincludes98aminoacidsmissingfromLaminC,whileLaminChasaC-terminal6aminoacidpeptidenotpresentinLaminA.ApartfromtheseregionsLaminAandCareidenticalsothatantibodiesraisedagainsteitherproteinarelikelytocrossreactwiththeother,asisthecasewiththismonoclonal.Laminpolymerizationanddepolymerizationisregulatedbyphosphorylationbycyclindependentproteinkinase1(CDK1),thekeycomponentof"maturationpromotingfactor",thecentralregulatorofcelldivision.ActivityofthiskinaseincreasesduringcelldivisionandisresponsIBLeforthebreakdownofthenuclearlamina.MutationsintheLMNAgeneareassociatedwithseveralserioushumandiseases,includingEmery-Dreifussmusculardystrophy,familialpartiallipodystrophy,limbgirdlemusculardystrophy,dilatedcardiomyopathy,Charcot-Marie-Toothdiseasetype2B1,andHutchinson-Gilfordprogeriasyndrome.ThisfamilyofdiseasesbelongtoalargergroupwhichareoftenreferredtoasLaminopathies,thoughsomelaminopathiesareassociatedindefectsinLaminB1,B2oroneorotherofthenumerousnuclearlaminabindingproteins.AtruncatedversionoflaminA,commonlyknownasprogerin,causesHutchinson-Gilfordprogeriasyndrome,aformofprematureaging(3).
BatchNo.Seeviallabel
Unitsize100uL
AntigenFulllengthrecombinanthumanLaminC
AntibodyTypePolyclonal
ProducedinRabbit
ApplicationsImmunocytochemistry(ICC)andWesternBlotting(WB).Adilutionof1:1,000-1:5,000isrecommendedforWB.Adilutionof1:1,000-1:5,000isrecommendedforICC.Theoptimaldilutionshouldbedeterminedbytheenduser.
SpecificityLaminAandLaminC.Theantibodyreactswitha74kDaand65kDabandbyWesternblotonHeLacellextract.IthasalsobeenusedsuccessfullyforimmunocytochemistryonHeLacellcultures.
SpeciesAgainstHuman,bovine,porcine,mouseandrat.Itisexpectedthatitwillworkonothermammaltissues.
FormLyophilizedfromPBS.Contains0.5%sodiumazide.
AppearanceWhitepowder
ReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
References1.Fisher,D.Z.,Chaudhary,N.,Blobel,G.CDNAsequencingofnuclearlaminsAandCrevealsprimaryandsecondarystructuralhomologytointermediatefilamentproteins.Proc.Nat.Acad.Sci.83:6450-6454(1986).2.McKeon,F.D.,Kirschner,M.W.,Caput,D.Homologiesinbothprimaryandsecondarystructurebetweennuclearenvelopeandintermediatefilamentproteins.Nature319:463-468(1986).3.Liu,B.andZhou,Z.LaminA/C,laminopathiesandprematureageing.Histol.Histopathol.23:747-763(2006).
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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